WebMay 3, 2009 · The transcription factor ELF4 controls hematopoietic stem cell quiescence. Lacorazza and colleagues show that ELF4 is also needed to maintain the quiescence of … WebMar 2, 2024 · Ctf4 organizes sister replisomes and Pol alpha into a replication factory. Elife. 2024; 8 e47405. Google Scholar), which could allow some degree of coordination of their movement ... Elife. 2024; 8 e47405. Google Scholar). However, in vitro evidence indicates that replisomes can function as monomers (Yardimci et al., 2010. Yardimci H. Loveland …
Evolutionary Repair Experiments as a Window to the Molecular …
WebAug 17, 2024 · As noted above, Ctf4 is a much less efficient substrate of SCF Dia2 than CMG (Figure 2D, compare Ctf4 and Mcm7), but Ctf4 … WebEvolutionary repair experiments can provide insight into the mechanistic aspects of evolutionary biology and illuminate novel cell-biological phenomena. We focus on the role of these experiments in understanding how cell biological functions evolve. We have structured this Review as follows. floorshield oregon
Transcription factor ELF4 controls the proliferation and ... - Nature
WebeLife 2024-07-13 Journal article DOI: 10.7554/eLife.77469 Contributors ... Ctf4 organizes sister replisomes and Pol α into a replication factory. eLife 2024-10-07 Journal article DOI: 10.7554/eLife.47405 Contributors ... WebAug 4, 2016 · These observations formed the basis for a model of the eukaryotic replisome, in which the CMG helicase is connected directly to the leading strand polymerase ε and … WebAug 4, 2016 · Ctf4 forms a homotrimer that has the potential to connect the CMG helicase to one or two Pol α complexes, via the α-helical bundle at the carboxyl terminus of each Ctf4 protomer, which binds to a short conserved motif in the GINS component of CMG and the Pol1 catalytic subunit of Pol α (Simon et al., 2014 ). great psychology movies